Exploring the Potential Impact of the Use of Probiotics on the Pharmacokinetics and the Pharmacodynamics of Drugs: A Narrative Review
Felix Keneolisa Asogwa
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani. Enugu State, Nigeria.
Daniel Lotanna Ajaghaku *
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani. Enugu State, Nigeria.
Augustine Oluchukwu Asogwa
Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria.
Celestine Obiora Ugwu
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani. Enugu State, Nigeria.
Detu Martins Ikpechukwu
Enugu State University of Science and Technology Teaching Hospital, Enugu State, Nigeria.
Kingsley Chidiebere Ndu
Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria Nsukka, Enugu State, Nigeria.
Linus Odinakachukwu Nsude
Department of Genetics and Biotechnology, State University of Science and Applied Sciences Igbo Eno, Enugu State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Probiotics are live microorganisms that, when administered in adequate amounts, confer health benefits to the host. Their impact on drug bioavailability and efficacy, particularly in gastrointestinal disorders, has gained considerable interest. This paper explores how probiotics can modulate the pharmacokinetics and pharmacodynamics of various medications used in treating gastrointestinal conditions such as irritable bowel syndrome, inflammatory bowel disease, and peptic ulcers. Probiotics may influence drug absorption, metabolism, and excretion through mechanisms such as alteration of gut microbiota composition, enhancement of intestinal permeability, and modulation of drug-metabolizing enzymes. The review synthesizes findings from recent studies demonstrating that probiotics can enhance drug efficacy by improving gut health and reducing inflammation. For instance, certain probiotic strains have been shown to increase the bioavailability of drugs by optimizing intestinal flora and reducing gastrointestinal disturbances. Conversely, probiotics may also impact drug metabolism, potentially leading to altered drug levels and effects. The paper discusses both the positive and negative implications of probiotic-drug interactions and highlights the need for individualized therapeutic strategies. Overall, while probiotics hold promise for improving drug outcomes in gastrointestinal conditions, their effects on drug bioavailability and efficacy require further investigation to ensure safe and effective therapeutic use.
Keywords: Probiotics, drug bioavailability, gastrointestinal disorders, drug-drug interactions, pharmacokinetics, intestinal microbiota