Seroprevalence of Human Papillomavirus Type 16 Immunoglobulin G Antibodies (HPV 16-IgG) among Women Attending General Hospital Kagarko, Kagarko Lga, Kaduna State
Joy Nkeiruka Dike-Ndudim
Department of Medical Laboratory Science, Faculty of Health Sciences, Imo State University Owerri, Imo State, Nigeria.
Sunday Olaniran Ayodeji
Department of Medical Laboratory Science, Faculty of Health Sciences, Imo State University Owerri, Imo State, Nigeria.
Chizaram Winners Ndubueze *
Department of Medical Laboratory Science, Faculty of Health Sciences, Imo State University Owerri, Imo State, Nigeria.
Chidinma Ursula Uwandu
Department of Medical Laboratory Science, Faculty of Health Sciences, Imo State University Owerri, Imo State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
A large majority of cervical cancer (more than 95%) is due to the Human Papillomavirus (HPV). The HPV type 16 account more than half of cervical cancers Worldwide. This study investigated the sero-prevalence of HPV-16 IgG antibodies among women attending General Hospital Kagarko, Kagarko Local government, Kaduna State. Serum samples and questionnaires were administered to 110 women for collection of data. HPV-16 specific IgG antibodies were detected by the use of an HPV-16 virus-like particle ELISA. The highest HPV-16 IgG sero-positivity 24.5% (27/110), was found at the age >20-59 years and at 95% confidence interval. Sero-positivity increased from 9.5% in women having one lifetime sex partner to 62.5% in women with more than three sex partners (p=0.006). Age at first intercourse, number of lifetime sex partners, and having had sex with men who have multiple sex partners were significantly associated with HPV-16 IgG antibodies. These information on HPV sero-epidemiology will be important for designing prevention efforts including vaccine programs.
Keywords: Human papilloma Virus, serology, prevalence, immunoglobulin, antibodies, women, Nigeria