https://journalijpr.com/index.php/IJPR <p style="text-align: justify;"><strong>International Journal of Pathogen Research</strong> <strong>(ISSN: 2582-3876) </strong>aims to publish high-quality papers related to all aspects of pathogens and pathogen-host interactions. The journal covers all pathogenic bacteria, viruses, fungi, prions, parasites, and protozoa that infect humans or animals, the diagnosis, management, or treatment for pathogen-related diseases, the diseases that have important medical, agricultural, and economic consequences as well as environmental and public health implications. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> International Journal of Pathogen Research en-US International Journal of Pathogen Research 2582-3876 https://journalijpr.com/index.php/IJPR/article/view/280 <p>Assessment of haematological and biochemical parameters can be predictive of the adverse effects resulting from ingesting foreign substances. Thus, the aim of this study was to evaluate the biochemical and haematological indices in <em>Plasmodium beighei</em> infected wistar rats. Freshly harvested leaves of <em>Sida</em> <em>cordifolia</em> were washed and dried at room temperature, after which they were ground to fine powder and subsequently extracted. Twenty-five adult Wistar rats were divided into five groups of five rats each. Group I was the normal control and was administered 2 ml of distilled of water. Group II was infected without treatment, while Group III and IV were infected and afterwards administered 200 and 400 mg/kg of aqueous extract of <em>Sida cordifolia</em> respectively. Group V was administered the standard drug. Biochemical and haematological indices were determined using standard procedures. The Packed Cell Volume (PCV) reported for group II (negative) control was significantly (P&lt;0.05) lower than that reported for the normal control. However, oral administration of 200 and 400 mg/kg of <em>Sida</em> <em>cordifolia</em> leaf extract significantly (P&lt;0.05) increased it, though to a level which was significantly (P&lt;0.05) lower than that reported for the normal control. Similar observation was made on Haemoglobin Concentration (Hb) and Red Blood Cell (RBC). However, a contrary observation was made on the white blood cell. Urea and creatinine reported for the negative control were significantly (P&lt;0.05) higher than those reported for the normal control. However, the aforementioned parameters were significantly (P&lt;0.05) reduced following oral administration of <em>Sida cordifolia</em>. In conclusion, it can be deduced from this study that <em>Sida</em> <em>cordifolia</em> leaf extract has the ability to restore distorted haematological and biochemical status resulting from <em>P. berghei</em> infection.</p> Ogwo Elisha Uko Obioma Elizabeth Nweke Okoye Ogochukwu Fidelis Ubani Clement Dimgba Suleiman Ali Sani Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2024-04-05 2024-04-05 13 3 1 5 10.9734/ijpr/2024/v13i3280